Tretten® (Coagulation Factor XIII A-Subunit [Recombinant])

Manny has congenital factor XIII deficiency

Tretten^® is the only recombinant therapy for congenital factor XIII A-subunit deficiency, a bleeding disorder affecting about 1 in every 1 to 3 million people

I would like more information about Tretten^®

I would like assistance with getting and using Tretten^®

I would like to talk to a Novo Nordisk Rare Blood Community Liaison (RBCL)

Who should not use Tretten^®?

You should not use Tretten^® if you have ever had allergic (hypersensitivity) reactions, including severe, whole body reaction (anaphylaxis) to Tretten^® or any of the ingredients.

What should I tell my healthcare provider before Tretten^® is given?

Tell your healthcare provider about all of your medical conditions, including if you are pregnant, think you may be pregnant or planning to become pregnant, are breast feeding, or have a history of blood clots.
Tell your healthcare provider and pharmacist about all of the medicines you take, including all prescription and non-prescription medicines such as over-the-counter medicines, supplements, or herbal remedies.

What is Tretten^® (Coagulation Factor XIII A-Subunit [Recombinant])?

Tretten^® is an injectable medicine used to prevent bleeding in adults and children who have congenital Factor XIII (FXIII) A-subunit deficiency.
Tretten^® is not for use in patients with congenital Factor XIII B-subunit deficiency.

Who should not use Tretten^®?

You should not use Tretten^® if you have ever had allergic (hypersensitivity) reactions, including severe, whole body reaction (anaphylaxis) to Tretten^® or any of the ingredients.

What should I tell my healthcare provider before Tretten^® is given?

Tell your healthcare provider about all of your medical conditions, including if you are pregnant, think you may be pregnant or planning to become pregnant, are breast feeding, or have a history of blood clots.
Tell your healthcare provider and pharmacist about all of the medicines you take, including all prescription and non-prescription medicines such as over-the-counter medicines, supplements, or herbal remedies.

What are the possible side effects of Tretten^®?

Call your healthcare provider or go to the emergency department right away if you have any of the following symptoms after using Tretten^®:
- Signs of allergic reaction, including shortness of breath, rash, itching (pruritus), redness of the skin (erythema), or fainting/dizziness.
- Signs of a blood clot including pain, swelling, warmth, redness, or a lump in your legs or arms, chest pain, or sudden severe headache and/or loss of consciousness or function.
- Unexpected bleeding.
Other possible side effects may include pain in your arms or legs, headache, and pain at the injection site.
These are not all the possible side effects of Tretten^®. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Please click here for Tretten^® Prescribing Information.

Tretten^® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.